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New York: Garland Science ; Search term Generation of lymphocytes in bone marrow and thymus The greater part of lymphocyte development in mammals occurs in the specialized environments of the central lymphoid organs—the bone marrow and the liver in the fetus for B cells and the thymus for T cells. In the fetus and the juvenile, these tissues are the source of large numbers of new lymphocytes , which migrate to populate the peripheral lymphoid tissues. In mature individuals, development of new T cells in the thymus slows down and T-cell numbers are maintained through division of mature T cells outside of the central lymphoid organs. New B cells, on the other hand, are continually produced from the bone marrow, even in adults.
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